Hydrochloric Acid → HCID 18956697, compound

HRID 1648825Notes

Reaction equation

HRID 1648825 reaction equation
[Al+3].[Cl-].[Cl-].[Cl-].[C:5]1([CH:11]([CH3:13])[CH3:12])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[N+:14]([C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=1)([O-:16])=[O:15].Cl>ClC1C=CC=CC=1>[CH:11]([C:5]1[CH:10]=[CH:9][C:8]([C:21]([C:20]2[CH:19]=[CH:18][C:17]([N+:14]([O-:16])=[O:15])=[CH:25][CH:24]=2)=[O:22])=[CH:7][CH:6]=1)([CH3:13])[CH3:12]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 7406CumeneHCID 85024-Nitrobenzoyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 18956697HCID 18956697, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent2×

Conditions

Temperature
60 °C

Procedure

710 parts of chlorobenzene and 160 parts of AlCl3 are initially introduced. A mixture of 120 parts of cumene, 185.6 parts of p-nitrobenzoyl chloride and 410 parts of chlorobenzene is added dropwise in the course of 1 hour at 20° to 25° C., HCl gas being liberated. The mixture is then heated in the course of 1 hour to 60° C. and stirred for 1 hour at 60° C., 1,400 parts of ice are added, the aqueous phase is separated off in a separating funnel and the organic phase is concentrated in vacuo. 247.6 parts of 4-isopropyl-4'-nitrobenzophenone having a melting point of 95° C. are obtained. Yield: 92% of theory.

Workup

  1. additionis added dropwise in the course of 1 hour at 20° to 25° C.
  2. temperatureThe mixture is then heated in the course of 1 hour to 60° C.
  3. addition1,400 parts of ice are added
  4. customthe aqueous phase is separated off in a separating funnel
  5. concentrationthe organic phase is concentrated in vacuo

Sources & evidence

ORD record
ord-fa23d2dbe4814f44bea560bee61067ce
Source dataset
uspto-grants-1983_11
Patent number
US04413144

Reaction notes

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