Methane → 5-acetyl-6-methyl-2(1H)-pyridinone

HRID 1649156Notes

Reaction equation

HRID 1649156 reaction equation
[C:1]([C:4]1[CH:12]=[C:8](C(O)=O)[C:7](=[O:13])[NH:6][C:5]=1[CH3:14])(=[O:3])[CH3:2].C>C(O)(C)C>[C:1]([C:4]1[CH:12]=[CH:8][C:7](=[O:13])[NH:6][C:5]=1[CH3:14])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 297MethaneHCID 132320405-Acetyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Product 1

HCID 44217365-acetyl-6-methyl-2(1H)-pyridinone

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A 10 g portion of 5-acetyl-1,2-dihydro-6-methyl-2-oxonicotinic acid was heated neat in a bath of a boiling mixture of diphenyl and diphenyl ether for 40 minutes and the mixture allowed to cool to room temperature. The reaction mixture was dissolved in hot isopropyl alcohol, treated with decolorizing charcoal and filtered, and the filtrate allowed to stand at room temperature for several hours. The separated product was collected and dried at 90°-95° C. to yield 4.3 g of 5-acetyl-6-methyl-2-(1H)-pyridinone, m.p. 193°-195° C.

Workup

  1. filtrationfiltered
  2. waitto stand at room temperature for several hours
  3. customThe separated product was collected
  4. customdried at 90°-95° C.

Sources & evidence

ORD record
ord-086c8f68f8614c858af471837ece8048
Source dataset
uspto-grants-1983_11
Patent number
US04415580

Reaction notes

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