Sodium Hydroxide → 8-Aminoquinolin-2(1H)-one

HRID 1649206Notes

Reaction equation

HRID 1649206 reaction equation
C([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH:11]=[CH:10]2)(=O)C.[OH-].[Na+]>Cl>[NH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH:11]=[CH:10]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13317110HCID 13317110, compound

Product 1

HCID 133171128-Aminoquinolin-2(1H)-oneYield 91.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

8-Acetylaminocarbostyril (21.5 g, 0.106 mol) was suspended in 190 ml of 20% hydrochloric acid and the suspension was stirred while heating under reflux for 1 hour. The reaction mixture was poured into ice water and neutralized with 5 N sodium hydroxide. Crystals which formed were collected by filtration to give 15.47 g of 8-aminocarbostyril.

Workup

  1. temperaturewhile heating
  2. temperatureunder reflux for 1 hour
  3. customCrystals which formed
  4. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-6d38258e6bc741be942b36a5bb376208
Source dataset
uspto-grants-1983_11
Patent number
US04415572

Reaction notes

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