反应详情

A mixture of 1.0 g of 5-(1-piperazinyl)-3,4-dihydrocarbostyril, 1.11 g of potassium carbonate, 760 mg of 4-methoxybenzyl chloride and 20 ml of DMF was stirred at 70°-80° C. for 4 hours. The reaction mixture was poured into a large amount of water and extracted with chloroform. After washing with water the extract was dried over anhydrous sodium sulfate. Chloroform was distilled off and the residue was purified through silica gel column chromatography. Recrystallization from methanol gave 60 mg of 5-[4-(4-methoxybenzyl)-1-piperazinyl]-3,4-dihydrocarbostyril, m.p. 194°-196° C., colorless needles.

1. extractionextracted with chloroform
2. washAfter washing with water the extract
3. dry with materialwas dried over anhydrous sodium sulfate
4. distillationChloroform was distilled off
5. customthe residue was purified through silica gel column chromatography
6. customRecrystallization from methanol