Hydrochloric Acid → HCID 20479683, compound

HRID 1649436Notes

Reaction equation

HRID 1649436 reaction equation
Cl.[N:2]1([C:8]2[C:19]3=[C:20]4[N:15]([CH:16]([CH3:21])[CH2:17][CH2:18]3)[CH:14]=[C:13]([C:22]([OH:24])=[O:23])[C:12](=O)[C:11]4=[CH:10][CH:9]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[OH-].[Na+].Cl>O>[N:2]1([C:8]2[C:19]3=[C:20]4[N:15]([CH:16]([CH3:21])[CH2:17][CH2:18]3)[CH:14]=[C:13]([C:22]([OH:24])=[O:23])[CH2:12][C:11]4=[CH:10][CH:9]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 70529023HCID 70529023, compound

Product 1

HCID 20479683HCID 20479683, compoundYield 94.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.8 g of 8-(1-piperazinyl)-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid hydrochloride was added to 100 ml of water and 1 N aqueous sodium hydroxide solution was added thereto followed by heating the mixture to form a uniform solution. The solution was rendered alkaline (pH=8) with dilute hydrochloric acid to obtain 3.1 g of 8-(1-piperazinyl)-5-methyl-6,7-dihydro-1H,5H-benzo[ij]quinolizine-2-carboxylic acid as colorless needles having a melting point of 264° to 265° C.

Workup

  1. additionwas added
  2. temperatureby heating the mixture
  3. customto form a uniform solution

Sources & evidence

ORD record
ord-7cf47e8d338545099905e86ea07c93fc
Source dataset
uspto-grants-1983_11
Patent number
US04416884

Reaction notes

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