Hydrochloric Acid → HCID 131713236, compound

HRID 1649557Notes

Reaction equation

HRID 1649557 reaction equation
[F:1][CH2:2][CH:3]([NH:18]C(OC(C)(C)C)=O)[CH:4]([F:17])[CH2:5][N:6]1C(=O)C2=CC=CC=C2C1=O.[ClH:26]>>[ClH:26].[ClH:26].[F:1][CH2:2][CH:3]([NH2:18])[CH:4]([F:17])[CH2:5][NH2:6]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 20479093HCID 20479093, compound

Product 1

HCID 131713236HCID 131713236, compound

Procedure

A mixture of 1,3-difluoro-2-tert.butoxycarbonylamino-4-phthalimidobutane (0.1 g, 0.27 mmol) obtained as in Step C above and concentrated hydrochloric acid is heated at 100° C. for 48 hours. The solvent is evaporated in vacuo and the residue is taken up in water. Insoluble phthalic acid is filtered off and the filtrate concentrated to yield 1,3-difluoro-2,4-diaminobutane, dihydrochloride (0.03 g).

Workup

  1. customobtained as in Step C above
  2. customThe solvent is evaporated in vacuo
  3. filtrationInsoluble phthalic acid is filtered off
  4. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-7070f52082f044e1ab277f2e174f2d7e
Source dataset
uspto-grants-1983_11
Patent number
US04418077

Reaction notes

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