Acetic Anhydride → HCID 19854190, compound

HRID 1649628Notes

Reaction equation

HRID 1649628 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][C:11](=[O:14])[CH2:10][C:9]2=[O:15])=[CH:4][CH:3]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>CN(C1C=CN=CC=1)C.C1(C)C=CC=CC=1>[C:16]([C:10]1[C:11](=[O:14])[CH2:12][CH2:13][CH:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[C:9]=1[OH:15])(=[O:18])[CH3:17]

Participants

5

Reactant 2

HCID 7918Acetic AnhydrideHCID 19854199HCID 19854199, compound

Product 1

HCID 19854190HCID 19854190, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 1140TolueneSolvent

Procedure

A solution of 4-(4-fluorophenyl)cyclohexane-1,3-dione (4 g), acetic anhydride (6 ml) and 4-(N,N-dimethylamino) pyridine (0.2 g) in toluene (50 ml) was refluxed 3 hours. Evaporation of the toluene in vacuo gave a red oil, which, after purification on a silica gel column using 5% (v/v) diethyl ether-methylene chloride as eluant, gave the title compound as a yeoolw solid (4 g) of m.p. 67°-68° C.

Workup

  1. customEvaporation of the toluene in vacuo
  2. customgave a red oil, which
  3. customafter purification on a silica gel column

Sources & evidence

ORD record
ord-81c83f461bdc4491a5d7a3612ec9b231
Source dataset
uspto-grants-1990_05
Patent number
US04921524

Reaction notes

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