(1,2-Dibromoethyl)benzene → HCID 14835198, compound

HRID 1649715Notes

Reaction equation

HRID 1649715 reaction equation
[SH:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[C:4]([NH2:9])[N:3]=1.[Br:10][CH:11]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:12]Br.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[BrH:10].[NH2:9][C:4]1[N:3]=[C:2]2[S:1][CH:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:12][N:7]2[C:6](=[NH:8])[CH:5]=1

Participants

5

Reactant 3

HCID 7145(1,2-Dibromoethyl)benzeneHCID 11430Potassium CarbonateHCID 1785079174,6-diaminopyrimidine-2-thiol

Product 1

HCID 14835198HCID 14835198, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
45 °C

Procedure

A mixture of 14.2 g (0.1 mole) of 2-mercapto-4,6-diamino-pyrimidine, 30.4 g (0.115 mole) of (1,2-dibromo-ethyl)-benzene, 200 ml of dimethyl formamide and 13.8 g (0.1 mole) of potassium carbonate is stirred at 45° C. for 6 hours. The reaction mixture is cooled, the precipitate is filtered, washed with water and dried. Thus 26.0 g of the desired compound are obtained, yield 80%, m.p.: above 300° C.

Workup

  1. temperatureThe reaction mixture is cooled
  2. filtrationthe precipitate is filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-9a3ad7d4939a46f195dfadc47e5f485f
Source dataset
uspto-grants-1990_05
Patent number
US04921854

Reaction notes

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