Aluminum(III) Chloride → 3-[4-(3-Phthalimidopropyl)benzoyl]-butyric acid methyl ester

HRID 1649720Notes

Reaction equation

HRID 1649720 reaction equation
[CH3:1][O:2][C:3]([CH2:5][CH:6]([CH3:10])[C:7](Cl)=[O:8])=[O:4].[C:11]1(=[O:30])[N:15]([CH2:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:14](=[O:25])[C:13]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:12]12.[Cl-].[Al+3].[Cl-].[Cl-]>ClCCCl>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH:6]([C:7](=[O:8])[C:22]1[CH:21]=[CH:20][C:19]([CH2:18][CH2:17][CH2:16][N:15]2[C:11](=[O:30])[C:12]3=[CH:29][CH:28]=[CH:27][CH:26]=[C:13]3[C:14]2=[O:25])=[CH:24][CH:23]=1)[CH3:10]

Participants

5

Reactant 3

HCID 6451240Aluminum(III) ChlorideHCID 76635292-(3-Phenyl-propyl)-isoindole-1,3-dioneHCID 14403282Methyl 4-chloro-3-methyl-4-oxobutanoate

Product 1

HCID 542111403-[4-(3-Phthalimidopropyl)benzoyl]-butyric acid methyl ester

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

8.2 g (50 mmol) of 3-methoxycarbonyl-2-methyl-propionic acid chloride and 13.3 g (50 mmol) of 3-phthalimidopropyl-benzene are reacted with 26 g of aluminum chloride in 1,2-dichloroethane analogously to Example 4(a). The oil obtained crystallizes from ethanol as beige coloured crystals.

Workup

  1. customThe oil obtained
  2. customcrystallizes from ethanol as beige coloured crystals

Sources & evidence

ORD record
ord-bd00b93da7974a9d88bd09892c4de700
Source dataset
uspto-grants-1990_05
Patent number
US04921856

Reaction notes

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