反应详情

温度

90 °C

A mixture of 1.0 g of 6-bromo-3,4-dihydrocarbostyril, 300 mg of imidazole, 40 mg of cuprous iodide and 600 mg of potassium carbonate in 4 ml of N,N-dimethylformamide was heated at 90° C. for 48 hours. The reaction mixture was poured into water and extracted with a mixture of 10% methanol in methylene chloride. The organic layer was dried over anhydrous sodium sulfate, the solvent removed under reduced pressure and the residue chromatographed on silica gel, eluting with 3% methanol in methylene chloride, giving 6-(imidazol-1-yl)-3,4-dihydrocarbostyril, m.p. 205°-208° C.

1. extractionextracted with a mixture of 10% methanol in methylene chloride
2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
3. customthe solvent removed under reduced pressure
4. customthe residue chromatographed on silica gel
5. washeluting with 3% methanol in methylene chloride