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HRID1649797

反应详情

EQUATION

反应方程式

HRID 1649797 的结构方程式

REACTANTS

反应物

4
结构：CN(C)C=O
HCID6228

N,N-Dimethylformamide

C3H7NO

结构：OCc1cc(Cl)cc(Cl)c1
HCID43236

3,5-Dichlorobenzylic alcohol

C7H6Cl2O

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：O=[N+]([O-])c1ccc(CCCOCCCCCCBr)nc1
HCID19854780

未命名化合物

PRODUCTS

生成物

1
结构：Nc1c(Cl)cc(C(O)CNCCCCCCOCCCc2ccc([N+](=O)[O-])cn2)cc1Cl
HCID19854821

未命名化合物

PROCEDURE

实验过程

A solution of 4-amino-α-aminomethyl)-3,5-dichlorobenzenemethanol (361 mg), 2-[3-[(6-bromohexyl)oxy]propyl]-5-nitropyridine (378 mg) and N,N-diisopropylethylamine (168 mg) in dimethylformamide (5 ml) was stirred at 100° for 3 h. The solvent was evaporated in vacuo to give an oil. Purification by FCC eluting with System A (95:5:1) gave the title compound as a yellow solid (250 mg), m.p. 60°-61°.

WORKUP

后处理

  1. customThe solvent was evaporated in vacuo
  2. customto give an oil
  3. customPurification by FCC
  4. washeluting with System A (95:5:1)