Water → HCID 178484691, compound

HRID 1649878Notes

Reaction equation

HRID 1649878 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[N:4][N:3]=1.C(N(CC)CC)C.[CH3:14][N:15]([CH3:19])[C:16](Cl)=[O:17].O>C(#N)C>[CH3:14][N:15]([CH3:19])[C:16](=[O:17])[NH:1][C:2]1[NH:6][N:5]=[N:4][N:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6598Dimethylcarbamoyl ChlorideHCID 8471TriethylamineHCID 178509299HCID 178509299, compound

Product 1

HCID 178484691HCID 178484691, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Anhydrous 5-aminotetrazole (8.5 g, 0.1 mole) was slurried in 150 ml of acetonitrile. On the addition of triethylamine (10 g, 0.1 mole), the solids dissolved. Dimethylcarbamoyl chloride (13 g, 0.12 mole) was added at once with no exotherm. The mixture was refluxed two hours with the formation of white solids. After cooling, the material was added to cold water to remove by-product triethylamine hydrochloride. The water insoluble material was collected.

Workup

  1. dissolutionthe solids dissolved
  2. temperatureThe mixture was refluxed two hours with the formation of white solids
  3. temperatureAfter cooling
  4. customto remove by-product triethylamine hydrochloride
  5. customThe water insoluble material was collected

Sources & evidence

ORD record
ord-ef0267e445914582973d0a3da5ad220d
Source dataset
uspto-grants-1990_05
Patent number
US04921965

Reaction notes

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