Hydrogen Bromide → 5-Amino-1-hydroxy-5,6,7,8-tetrahydro-naphthalene hydrobromide

HRID 1649936Notes

Reaction equation

HRID 1649936 reaction equation
Cl.[NH2:2][CH:3]1[CH2:12][CH2:11][CH2:10][C:9]2[C:8]([O:13]C)=[CH:7][CH:6]=[CH:5][C:4]1=2.[BrH:15]>>[BrH:15].[NH2:2][CH:3]1[CH2:12][CH2:11][CH2:10][C:9]2[C:8]([OH:13])=[CH:7][CH:6]=[CH:5][C:4]1=2

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 703499325-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride

Product 1

HCID 198554515-Amino-1-hydroxy-5,6,7,8-tetrahydro-naphthalene hydrobromideYield 80%

Procedure

0.15 mol of 5-amino-1-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride is heated at a bath temperature of 125° C. in 75 ml of aqueous 48% strength HBr for 3 hours. The mixture is evaporated, the residue is dissolved in a little ethanol and the products are precipitated as the hydrobromides by addition of ether. Yield: 80% of theory; melting point: 152° C.

Workup

  1. customThe mixture is evaporated
  2. dissolutionthe residue is dissolved in a little ethanol
  3. customthe products are precipitated as the hydrobromides by addition of ether

Sources & evidence

ORD record
ord-ecb9f35df730436fa83e64da16c2b12d
Source dataset
uspto-grants-1990_05
Patent number
US04921998

Reaction notes

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