Hydrochloric Acid → HCID 19855554, compound

HRID 1649994Notes

Reaction equation

HRID 1649994 reaction equation
[CH2:1]([N:3]([CH2:7][CH:8]([NH:10][C:11]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:18])[CH3:9])C(=O)C)[CH3:2].[ClH:19]>>[ClH:19].[ClH:19].[CH2:1]([NH:3][CH2:7][CH:8]([NH:10][C:11]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:18])[CH3:9])[CH3:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 13674870HCID 13674870, compound

Product 1

HCID 19855554HCID 19855554, compoundYield 56%

Procedure

A mixture of 0.3 g (1.2 mmoles) of 1-(N-ethyl-acetamido)-2-(2,6-dimethylphenyl-amino)-propane and 5 ml of a 20% aqueous hydrochloric acid solution is boiled for 3 hours. The solvent is evaporated, and the residue is dissolved in 30 ml of water. The solution is washed five times with 5 ml of chloroform, each, and then the solvent is evaporated. The residue is crystallized from a mixture of chloroform and diethyl ether to obtain 0.14 g (56%) of 1-ethylamino-2-(2,6-dimethylphenyl-amino)-propane dihydrochloride; m.p.: 155°-157° C.

Workup

  1. customThe solvent is evaporated
  2. dissolutionthe residue is dissolved in 30 ml of water
  3. washThe solution is washed five times with 5 ml of chloroform
  4. customeach, and then the solvent is evaporated
  5. customThe residue is crystallized from a mixture of chloroform and diethyl ether

Sources & evidence

ORD record
ord-039a496512034970b128df4f9ed02e1c
Source dataset
uspto-grants-1990_05
Patent number
US04922021

Reaction notes

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