Triethylamine → HCID 23043913, compound

HRID 1650012Notes

Reaction equation

HRID 1650012 reaction equation
Cl[C:2]([CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10]C)=[O:9])=[O:3].[CH:12]1([CH2:18][CH2:19][NH2:20])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.C(N(CC)CC)C>ClCCl>[CH:12]1([CH2:18][CH2:19][NH:20][C:2](=[O:3])[CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 205092-CyclohexylethylamineHCID 520737Methyl 6-chloro-6-oxohexanoate

Product 1

HCID 23043913HCID 23043913, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Methyl 5-[chloroformyl]pentanoate (4.2 g) in dry dichloromethane (20 ml) was added dropwise to a stirred solution of 2-cyclohexylethylamine (3 g) and triethylamine (3.3 ml) in dry dichloromethane (40 ml) under a N2 atmosphere. The mixture was stirred at room temperature for 16 hours and heated under reflux for 1.5 hours.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 1.5 hours

Sources & evidence

ORD record
ord-358b0f73fe0949889373bf715257652f
Source dataset
uspto-grants-1990_05
Patent number
US04922022

Reaction notes

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