反应详情

In ethanol was dissolved 5.0 g of 4-hydroxy-3-chlorophenol, and an aqueous solution of 1.38 g of sodium hydroxide and 8.6 g of n-dodecyl bromide were added to the solution under reflux in a nitrogen atmosphere. The mixture was refluxed for 6 hours and cooled, and the thus-obtained solution was put into a 1N aqueous solution of hydrochloric acid and extracted with chloroform. The extract was washed with a saturated aqueous solution of sodium chloride, dehydrated on anhydrous magnesium sulfate and concentrated. The concentrate was purified by using a silica gel column to obtain 1.73 g of 4-dodecyloxy-3-chlorophenol.

1. temperatureunder reflux in a nitrogen atmosphere
2. temperatureThe mixture was refluxed for 6 hours
3. temperaturecooled
4. extractionextracted with chloroform
5. washThe extract was washed with a saturated aqueous solution of sodium chloride
6. concentrationconcentrated
7. customThe concentrate was purified