HRID1650644

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24758

Sodium hydride

HNa

HCID22221580

3-Chloro-4-(methoxymethoxy)phenol

C8H9ClO3

HCID23052179

1-(Bromomethyl)-4-(dodecyloxy)benzene

C19H31BrO

PRODUCTS

生成物

结构：CCCCCCCCCCCCOc1ccc(Cc2c(Oc3ccc(OCOC)c(Cl)c3Cc3ccc(OCCCCCCCCCCCC)cc3)ccc(OCOC)c2Cl)cc1

HCID57105621

未命名化合物

收率 58.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

In dimethylformamide, 2 g of 4-dodecyloxybenzyl bromide synthesized in the same manner as described in Referential Example 17 was reacted with 1.5 g of 4-methoxymethyloxy-3-chlorophenol synthesized in the same manner as described in Example 11 in the presence of NaH to obtain 1.5 g of 4-dodecyloxybenzyl(4-methoxymethyloxy-3-chlorophenyl) ether. According to customary procedures, the methoxymethyl group was removed from the so-obtained compound in the presence of zinc in acetic acid to obtain 1.2 g of 4-dodecyloxybenzyl(4-hydroxy-3-chlorophenyl) ether.

WORKUP

后处理

customsynthesized in the same manner

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8a60b4385bf64dad8a53c453d3df97ef
来源数据集: uspto-grants-1990_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04925591
来源说明: uspto-grants-1990_05

反应 SMILES

[CH2:1]([O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Br)=[CH:16][CH:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[CH3:22][O:23][CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][C:27]=1[Cl:33].[H-].[Na+]>CN(C)C=O>[CH2:1]([O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][C:28]2[C:27]([Cl:33])=[C:26]([O:25][CH2:24][O:23][CH3:22])[CH:31]=[CH:30][C:29]=2[O:32][C:29]2[CH:30]=[CH:31][C:26]([O:25][CH2:24][O:23][CH3:22])=[C:27]([Cl:33])[C:28]=2[CH2:18][C:17]2[CH:20]=[CH:21][C:14]([O:13][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])=[CH:15][CH:16]=2)=[CH:16][CH:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]