Hydrochloric Acid → HCID 53758232, compound

HRID 1650710Notes

Reaction equation

HRID 1650710 reaction equation
[C:1]([NH:4][C:5]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[C:6]([CH3:12])[C:7]([O:9]CC)=[O:8])(=[O:3])[CH3:2].[OH-].[Na+].O.Cl>C(O)(C)C>[C:1]([NH:4][C:5]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)=[C:6]([CH3:12])[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 53702067HCID 53702067, compound

Product 1

HCID 53758232HCID 53758232, compoundYield 59.2%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

80 g of the product of Step A were stirred for 5 hours in 400 ml of isopropanol and 48.5 ml of sodium hydroxide and the solution was poured into a liter of water taken to pH 1 with concentrated hydrochloric acid. The precipitate was separated, washed with water and dried under reduced pressure to obtain 42 g of the expected product melting at 190° C.

Workup

  1. customThe precipitate was separated
  2. washwashed with water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-b7690e463f2a4891b168dabb9e1301c0
Source dataset
uspto-grants-1990_05
Patent number
US04925859

Reaction notes

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