反应详情

温度

50 °C

To the solution of ethyl 4-undecylphenylacetate (7.2 g, 0.023 mol) in a mixture of methanol (40 ml) and tetrahydrofuran (40 ml) was added sodium hydroxide (2.2 g, 0.055 mol) and stirred at 50° C. for 20 minutes. The reaction mixture was adjusted to pH 4 with 2N hydrochloric acid after concentration. The resultant mixture was extracted with ethyl acetate, and the organic layer was washed with water, dried and concentrated under reduced pressure. The resulting crude crystals were recrystallized from hexane to obtain 4-undecylphenylacetic acid (3-x, 1.8 g, 27%). m.p. 83°-84° C.

1. concentrationafter concentration
2. extractionThe resultant mixture was extracted with ethyl acetate
3. washthe organic layer was washed with water
4. customdried
5. concentrationconcentrated under reduced pressure
6. customThe resulting crude crystals were recrystallized from hexane