反应详情

The reaction was performed as in Example 87 using sodium hydride (56% dispersion in oil; 9.5 g) dimethylsulfoxide (100 mL), (3-carboxypropyl)triphenylphosphonium chloride (35 g); 4,4'-dimethoxybenzophenone (26.4 g); and tetrahydrofuran (100 mL). After the usual work up, the crude acid was crystallized from dichloromethane-hexane to give 15.6 g of 5,5-bis(4-methoxyphenyl)-4-pentenoic acid, mp 113°-114° C. Anal. Calculated for C19H20O4 : C, 73.06; H, 6.45. Found: C, 73.00; H, 6.45.

1. customAfter the usual work up, the crude acid was crystallized from dichloromethane-hexane