Hydrochloric Acid → Triazole,3-nitro-1-(2-fluoro-3-hydroxy)propyl-

HRID 1651300Notes

Reaction equation

HRID 1651300 reaction equation
Cl.[F:2][CH:3]([CH2:13][O:14]C(=O)C)[CH2:4][N:5]1[CH:9]=[N:8][C:7]([N+:10]([O-:12])=[O:11])=[N:6]1>>[F:2][CH:3]([CH2:13][OH:14])[CH2:4][N:5]1[CH:9]=[N:8][C:7]([N+:10]([O-:12])=[O:11])=[N:6]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 23051825HCID 23051825, compound

Product 1

HCID 23273731Triazole,3-nitro-1-(2-fluoro-3-hydroxy)propyl-Yield 66.8%

Procedure

2N-HCl was added to 420 mg (1.81 mmol) of 1-(2'fluoro-3'-acetoxypropyl)-3-nitro-1,2,4-triazole and stirred overnight at room temperature. Then, the reaction solution was concentrated and subjected to isolation and purification by silica gel column chromatography to give 230 mg of 1-(2'-fluoro-3'-hydroxypropyl)-3-nitro-1,2,4-triazole.

Workup

  1. concentrationThen, the reaction solution was concentrated
  2. customsubjected to isolation and purification by silica gel column chromatography

Sources & evidence

ORD record
ord-5e8d88433048447a9f1f413993a787b0
Source dataset
uspto-grants-1990_05
Patent number
US04927941

Reaction notes

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