反应详情

Tertiary-butyl 2-methoxyimino-3-oxobutyrate (805 g) was dissolved in 2.8 liters of methylene chloride. Hydrogen chloride (210 g) was blown into the solution at 3° to 6° C. over 8 hours. Then, the resultant mixture was allowed to stand at 5° C. for 15 hours. The supernatant was concentrated to dryness to give 556 g of 2-methoxyimino-3-oxobutyric acid as a crystalline solid.

1. concentrationThe supernatant was concentrated to dryness