Hydrazine hydrate (1:1) → HCID 13773325, compound

HRID 1651467Notes

Reaction equation

HRID 1651467 reaction equation
[C:1]12([C:11]([S:13]C)=S)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.O.[NH2:16][NH2:17]>CO>[C:1]12([C:11]([NH:16][NH2:17])=[S:13])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13773324HCID 13773324, compound

Product 1

HCID 13773325HCID 13773325, compoundYield 86.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the product of step (a) (1 g) in methanol (50 ml) was treated with hydrazine hydrate (0.3 g) and the mixture stirred at room temperature for 1 hour. The solvent was evaporated, the residue triturated with water, and the pH adjusted to 7 to give the sub-title product (0.8 g) as a white solid.

Workup

  1. customThe solvent was evaporated
  2. customthe residue triturated with water

Sources & evidence

ORD record
ord-3966b38de4b84204a7f3b41a6bcef132
Source dataset
uspto-grants-1990_05
Patent number
US04927822

Reaction notes

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