Ethyl Acrylate → HCID 53862841, compound

HRID 1651514Notes

Reaction equation

HRID 1651514 reaction equation
[CH3:1][C:2]12[CH2:9][CH:6]([NH:7][CH2:8]1)[CH2:5][C:4]([CH3:11])([CH3:10])[CH2:3]2.[C:12]([O:16][CH2:17][CH3:18])(=[O:15])[CH:13]=[CH2:14]>C(OCC)C>[CH2:17]([O:16][C:12](=[O:15])[CH2:13][CH2:14][N:7]1[CH2:8][C:2]2([CH3:1])[CH2:9][CH:6]1[CH2:5][C:4]([CH3:11])([CH3:10])[CH2:3]2)[CH3:18]

Participants

4

Reactant 2

HCID 8821Ethyl AcrylateHCID 1037871,3,3-Trimethyl-6-azabicyclo(3.2.1)octane

Product 1

HCID 53862841HCID 53862841, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

15.3 g of 1,3,3-trimethyl-6-aza-bicyclo[3,2,1]octane (0.15 mol) are introduced into 50 ml of diethyl ether, and 15.1 g of ethyl acrylate are gradually added thereto while stirring. A clear solution forms with a slight increase in temperature. After standing overnight at room temperature, the ether is distilled off. The oil which remains is distilled in vacuo to give 3-(1,3,3-trimethyl-6-aza-bicyclo[3,2,1]oct-6-yl)-propionic acid ethyl ester, b.p. 77°/0.013 mbar.

Workup

  1. additionare gradually added
  2. temperatureA clear solution forms with a slight increase in temperature
  3. distillationthe ether is distilled off
  4. distillationThe oil which remains is distilled in vacuo

Sources & evidence

ORD record
ord-a0238c05637b4b50a2846efaa01bb507
Source dataset
uspto-grants-1990_05
Patent number
US04929606

Reaction notes

Loading…