Sulfuric acid magnesium salt (1:1) → HCID 14986942, compound

HRID 1651532Notes

Reaction equation

HRID 1651532 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH:15]([CH3:18])[CH2:16][OH:17])=[CH:11][CH:10]=[CH:9][CH:8]=2)([O-])=O.S([O-])([O-])(=O)=O.[Mg+2].[H][H]>C(OCC)(=O)C.[Pt]>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH:15]([CH3:18])[CH2:16][OH:17])=[CH:11][CH:10]=[CH:9][CH:8]=2

Participants

6

Reactant 3

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 14700381HCID 14700381, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14986942HCID 14986942, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 27.9 g (0.113 mole) of 2-[(3-nitro-4-quinolinyl)amino]-1-propanol in 1.2 l of ethyl acetate, 28 g of magnesium sulfate and 2.0 g of 5% platinum on charcoal was hydrogenated on a Paar apparatus until hydrogen uptake was completed. The catalyst and solid residue were removed by filtration and the filtrate was concentrated by evaporation to provide 2-[(3-amino-4-quinolinyl)amino]-1-propanol as a yellow oil.

Workup

  1. customThe catalyst and solid residue were removed by filtration
  2. concentrationthe filtrate was concentrated by evaporation

Sources & evidence

ORD record
ord-b730c1363c814ee69343278ae7498f1f
Source dataset
uspto-grants-1990_05
Patent number
US04929624

Reaction notes

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