Hydrochloric Acid → HCID 54104191, compound

HRID 1651859Notes

Reaction equation

HRID 1651859 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[Cl:5][CH2:6][C:7](Cl)=[O:8].[C:10]1([CH3:29])[CH:15]=[CH:14][C:13]([S:16]([NH:19][CH:20]2[CH2:28][C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:21]2)(=[O:18])=[O:17])=[CH:12][CH:11]=1.Cl>C(Cl)CCl>[Cl:5][CH2:6][C:7]([C:24]1[CH:23]=[C:22]2[C:27](=[CH:26][CH:25]=1)[CH2:28][CH:20]([NH:19][S:16]([C:13]1[CH:12]=[CH:11][C:10]([CH3:29])=[CH:15][CH:14]=1)(=[O:17])=[O:18])[CH2:21]2)=[O:8]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 53802754HCID 53802754, compound

Product 1

HCID 54104191HCID 54104191, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

25.4 g (0.19 mol) of anhydrous aluminium chloride are suspended in 80 ml of ethylene chloride and 11.1 g (0.095 mol) of chloroacetyl chloride are added. 22.8 g (0.079 mol) of 2-p-toluenesulphonamido-indane are then added and the mixture is stirred for 2 hours at room temperature. The product is then decomposed by means of ice and hydrochloric acid and the reaction product is isolated from the organic phase and recrystallised from ethyl acetate/cyclohexane.

Workup

  1. customthe reaction product is isolated from the organic phase
  2. customrecrystallised from ethyl acetate/cyclohexane

Sources & evidence

ORD record
ord-363262bdc9524783b2a45cbe5e394b24
Source dataset
uspto-grants-1990_05
Patent number
US04929754

Reaction notes

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