Piperidine → HCID 178499397, compound

HRID 1651903Notes

Reaction equation

HRID 1651903 reaction equation
C1CCNCC1.COC(=O)CC1CCc2cc(Br)cc3[nH]c(=O)c(=O)n1c23>C1CN2CCN1CC2.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.COCCOC.CS(C)=O.F[P-](F)(F)(F)(F)F.Fc1cc(F)c(-c2ccc(C(F)(F)F)cn2)[c]([Ir+][c]2cc(F)cc(F)c2-c2ccc(C(F)(F)F)cn2)c1.[Cl][Ni][Cl]>COC(=O)CC1CCc2cc(N3CCCCC3)cc3[nH]c(=O)c(=O)n1c23

Participants

7

Reactant 2

HCID 8082PiperidineHCID 10066635Methyl 2-(9-bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyrido[1,2,3-de]quinoxalin-5-yl)acetate

Product 1

HCID 178499397HCID 178499397, compoundYield 0%

Reagents, catalysts & solvents 4

HCID 9237DabcoCatalystHCID 15773433Dichloronickel;1,2-dimethoxyethaneCatalystHCID 178441141HCID 178441141, compoundCatalystHCID 679Dimethyl SulfoxideSolvent3×

Conditions

Temperature
55 °C

Workup

  1. additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
  2. aliquot25 microliter of quenched reaction mixture was taken
  3. additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

Sources & evidence

ORD record
ord-3ff08768faa24fa8b8c5ad81eccc7206
Source dataset
Nano CN PhotoChemistry Informers Library
Original link
View source

Reaction notes

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