Tetrahydrofuran → 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(3-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-5-yl)urea
Reaction equation
[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1.[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([O:15][c:16]3[cH:17][c:18]([NH2:19])[cH:20][cH:21][cH:22]3)[n:7][cH:8][n:9][c:10]2[cH:11][c:12]1[O:13][CH3:14].[CH3:51][N:52]([CH3:53])[c:54]1[cH:55][cH:56][n:57][cH:58][cH:59]1.[F:23][C:24]([C:25]([CH3:26])([CH3:27])[c:28]1[n:29][o:30][c:31]([NH:33][C:34]([O:35][c:37]2[cH:38][cH:39][c:40]([Cl:41])[cH:42][cH:43]2)=[O:36])[cH:32]1)([F:44])[F:45]>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([O:15][c:16]3[cH:17][c:18]([NH:19][C:34]([NH:33][c:31]4[o:30][n:29][c:28]([C:25]([C:24]([F:23])([F:44])[F:45])([CH3:26])[CH3:27])[cH:32]4)=[O:35])[cH:20][cH:21][cH:22]3)[n:7][cH:8][n:9][c:10]2[cH:11][c:12]1[O:13][CH3:14]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-2c78e93fedeb4d738f23f9fc509c2983
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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