Hydrochloric Acid → ethyl (2RS,3RS)-3-(4-fluorophenyl)-3-hydroxy-2-(4-isopropylbenzyl)propionate

HRID 165227Notes

Reaction equation

HRID 165227 reaction equation
[BH4-:32].[BH4-:34].[CH3:27][CH2:28][O:29][CH2:30][CH3:31].[ClH:26].[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]([CH:9]([C:10](=[O:11])[O:12][CH2:13][CH3:14])[CH2:15][c:16]2[cH:17][cH:18][c:19]([CH:22]([CH3:23])[CH3:24])[cH:20][cH:21]2)=[O:25])[cH:6][cH:7]1.[Zn+2:33]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH:9]([C:10](=[O:11])[O:12][CH2:13][CH3:14])[CH2:15][c:16]2[cH:17][cH:18][c:19]([CH:22]([CH3:23])[CH3:24])[cH:20][cH:21]2)[OH:25])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 28123Borohydride2×HCID 32051Zinc(2+)HCID 22261387Ethyl 3-(4-fluorophenyl)-2-(4-isopropylbenzyl)-3-oxopropionate

Product 1

HCID 86593227ethyl (2RS,3RS)-3-(4-fluorophenyl)-3-hydroxy-2-(4-isopropylbenzyl)propionate

Sources & evidence

ORD record
ord-788e665721d647689b7f9e3fc9e2feca
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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