Dimethyl Sulfoxide → Hydrochloric Acid

HRID 165332Notes

Reaction equation

HRID 165332 reaction equation
[CH3:40][S:41]([CH3:42])=[O:43].[Cl:25][c:26]1[n:27][cH:28][n:29][c:30]2[cH:31][c:32]([O:38][CH3:39])[c:33]([O:36][CH3:37])[cH:34][c:35]12.[H-:23].[Na+:24].[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][NH:9][S:10](=[O:11])(=[O:12])[c:13]2[cH:14][c:15]3[c:19]([cH:20][cH:21]2)[NH:18][C:17](=[O:22])[CH2:16]3)[CH2:5][CH2:6]1.[O:44]=[CH:45][N:46]([CH3:47])[CH3:48]>>[ClH:25].[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][NH:9][S:10](=[O:11])(=[O:12])[c:13]2[cH:14][c:15]3[c:19]([cH:20][cH:21]2)[NH:18][C:17](=[O:22])[CH:16]3[c:26]2[n:27][cH:28][n:29][c:30]3[cH:31][c:32]([O:38][CH3:39])[c:33]([O:36][CH3:37])[cH:34][c:35]23)[CH2:5][CH2:6]1

Participants

8

Reactant 6

HCID 679Dimethyl SulfoxideHCID 923Sodium ionHCID 6228DimethylformamideHCID 166653HydrideHCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 217173035-(2-Morpholinoethylaminosulphonyl)oxindole

Product 2

HCID 313Hydrochloric AcidHCID 217171763-(6,7-dimethoxyquinazolin-4-yl)-N-(2-morpholin-4-ylethyl)-2-oxo-1,3-dihydroindole-5-sulfonamide

Sources & evidence

ORD record
ord-92abae07e60647b182f496500b414fb5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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