Piperidine → HCID 178473333, compound

HRID 1653360Notes

Reaction equation

HRID 1653360 reaction equation
C1CCNCC1.CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(Br)cnc32)CC1>C1=CC2Sc3ccccc3N(c3ccccc3)C2C=C1.C1CN2CCN1CC2.COCCOC.CS(C)=O.[Cl][Ni][Cl]>CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cc(N4CCCCC4)cnc32)CC1

Participants

7

Reactant 2

HCID 8082PiperidineHCID 10742688Ethyl 4-(3-bromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Product 1

HCID 178473333HCID 178473333, compoundYield 0%

Reagents, catalysts & solvents 4

HCID 9237DabcoCatalystHCID 15773433Dichloronickel;1,2-dimethoxyethaneCatalystHCID 148719639HCID 148719639, compoundCatalystHCID 679Dimethyl SulfoxideSolvent3×

Conditions

Temperature
55 °C

Workup

  1. additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
  2. aliquot25 microliter of quenched reaction mixture was taken
  3. additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

Sources & evidence

ORD record
ord-aad9e845f8d742e6af93e7f867a1e8cd
Source dataset
Nano CN PhotoChemistry Informers Library
Original link
View source

Reaction notes

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