Piperidine → HCID 178523006, compound

HRID 1653461Notes

Reaction equation

HRID 1653461 reaction equation
C1CCNCC1.O=C(NCc1ccc(F)cc1)c1nc(Br)c2cccnc2c1O>C1CN2CCN1CC2.COCCOC.CS(C)=O.FC(F)(F)C1=CC2Sc3ccccc3N(c3ccccc3)C2C=C1.FC(F)(F)c1cc(-c2c3ccccc3[n+](-c3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc23)cc(C(F)(F)F)c1.[Cl-].[Cl][Ni][Cl]>O=C(NCc1ccc(F)cc1)c1nc(N2CCCCC2)c2cccnc2c1O

Participants

8

Reactant 2

HCID 8082PiperidineHCID 223464015-bromo-N-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide

Product 1

HCID 178523006HCID 178523006, compoundYield 2.226%

Reagents, catalysts & solvents 5

HCID 9237DabcoCatalystHCID 15773433Dichloronickel;1,2-dimethoxyethaneCatalystHCID 178506060HCID 178506060, compoundCatalystHCID 178506066HCID 178506066, compoundCatalystHCID 679Dimethyl SulfoxideSolvent3×

Conditions

Temperature
55 °C

Workup

  1. additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
  2. aliquot25 microliter of quenched reaction mixture was taken
  3. additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

Sources & evidence

ORD record
ord-fc95573f5b604d45ba054dc20594088e
Source dataset
Nano CN PhotoChemistry Informers Library
Original link
View source

Reaction notes

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