HCID 15239992, compound → methyl 6-(N,N-dimethylamino)-3-hydroxypicolinate

HRID 1653643Notes

Reaction equation

HRID 1653643 reaction equation
C([O:8][C:9]1[C:10]([C:18]([O:20][CH3:21])=[O:19])=[N:11][C:12]([N:15]([CH3:17])[CH3:16])=[CH:13][CH:14]=1)C1C=CC=CC=1>[C].[Pd].C(OCC)(=O)C>[CH3:17][N:15]([C:12]1[N:11]=[C:10]([C:18]([O:20][CH3:21])=[O:19])[C:9]([OH:8])=[CH:14][CH:13]=1)[CH3:16]

Participants

4

Reactant 1

HCID 15239992HCID 15239992, compound

Product 1

HCID 15767145methyl 6-(N,N-dimethylamino)-3-hydroxypicolinate

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

2.3 g (8 mmol) of methyl 3-benzyloxy-6-(N,N-dimethylamino)picolinate and 0.3 g of 10% palladium carbon were added to 100 ml of ethyl acetate, and the mixture was hydrogenated under atmospheric pressure. After completion of the reaction, the product was filtered and concentrated to obtain crystals.

Workup

  1. customAfter completion of the reaction
  2. filtrationthe product was filtered
  3. concentrationconcentrated
  4. customto obtain crystals

Sources & evidence

ORD record
ord-119bbbed187147449d212ea1efbaeb9e
Source dataset
uspto-grants-1995_04
Patent number
US05403816

Reaction notes

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