反应详情

Benzylchloroformate (12.2 g, 72 mmol) was added dropwise to a stirred solution, at 0° C., of 4-fluorophenylethyl amine (9.42 g, 72 mmol) in 50 mL of DMF. The mixture was stirred for an additional 3 hours at the same temperature. The reaction was quenched with water and extracted with 3×100 mL of ethyl acetate. The combined ethyl acetate extracts were washed with 2×100 mL of 5% HCl, water and dried over Na2SO4. Evaporation of the solvent resulted in a yellowish solid which was purified by recrystallization from ethyl acetate-hexane to furnish 8.6 g (46% yield) of N-Benzyloxycarbonyl-2-(parafluorophenyl)ethylamine. mp 51°-52° C.

1. customThe reaction was quenched with water
2. extractionextracted with 3×100 mL of ethyl acetate
3. washThe combined ethyl acetate extracts were washed with 2×100 mL of 5% HCl, water
4. dry with materialdried over Na2SO4
5. customEvaporation of the solvent
6. customresulted in a yellowish solid which
7. customwas purified by recrystallization from ethyl acetate-hexane