Methyl iodide → 1-Methyl-3-triphenylmethyl-5(3-methyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidinium Iodide

HRID 1653728ノート

反応式

HRID 1653728 の反応式
[CH3:1][I:2].[C:3]1([C:9]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:10]2[CH2:15][CH:14]([C:16]3[O:20][N:19]=[C:18]([CH3:21])[N:17]=3)[CH2:13][N:12]=[CH:11]2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(Cl)(Cl)Cl>[I-:2].[CH3:1][NH+:12]1[CH2:13][CH:14]([C:16]2[O:20][N:19]=[C:18]([CH3:21])[N:17]=2)[CH2:15][N:10]([C:9]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:11]1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 100244281-Triphenylmethyl-1,4,5,6-tetrahydro-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyrimidine

生成物 1

HCID 703426091-Methyl-3-triphenylmethyl-5(3-methyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidinium Iodide収率 100%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Methyliodide (38 μl, 0.6 mmol) was added to a stirred solution of 1-triphenylmethyl-5(3-methyl-1,2,4-oxadiazol-5-yl) -1,4,5,6-tetrahydropyrimidine (250 mg, 0.6 mmol) in chloroform (1 ml), in a round bottom flask with a septum, at room temperature. After 12 hours stirring the solvents were evaporated in vacuo giving 330 mg (100%) crude white crystals identified by 300 MHz nmr.

後処理

  1. customwere evaporated in vacuo

出典と根拠

ORDレコード
ord-798c4160d5d44c5e9b02f5ae1b94de55
出典データセット
uspto-grants-1995_04
特許番号
US05403845

反応ノート

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