Ammonium Chloride → HCID 178477983, compound

HRID 1653814Notes

Reaction equation

HRID 1653814 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]#[N:26])[O:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.[N-:27]=[N+:28]=[N-:29].[Na+].[Cl-].[NH4+]>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]3[NH:29][N:28]=[N:27][N:26]=3)[O:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 25517Ammonium Chloride2×HCID 33557Sodium Azide2×HCID 20080521HCID 20080521, compound

Product 1

HCID 178477983HCID 178477983, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The procedure is as in Example 2, heating for 48 hours 2.4 g of 6-[4,5-bis(4-chlorophenyl)-2-oxazolyl]hexanenitrile, 1.2 g of sodium azide and 1 g of ammonium chloride in 45 cm3 of dimethylformamide. Sodium azide and ammonium chloride are added (in the same quantities as before) and the mixture is brought again to 105° C. for 48 hours. The reaction product is extracted as in the abovementioned example and crystallised in 80 cm3 of diisopropyl ether. 1.2 g of 5-{5-[4,5-bis(4-chlorophenyl)-2-oxazolyl]pentyl}tetrazole, white crystals, melting point 100° C., are obtained.

Workup

  1. customcrystallised in 80 cm3 of diisopropyl ether

Sources & evidence

ORD record
ord-535c970271004898a4ad8b956031b25e
Source dataset
uspto-grants-1995_04
Patent number
US05403852

Reaction notes

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