2-Amino-2,3-dimethylbutanamide → HCID 15672409, compound

HRID 1653980Notes

Reaction equation

HRID 1653980 reaction equation
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:7]=[C:8]2[C:15](=[O:16])[O:14][C:12](=[O:13])[C:9]2=[N:10][CH:11]=1.[NH2:17][C:18]([CH3:25])([CH:22]([CH3:24])[CH3:23])[C:19]([NH2:21])=[O:20]>O1CCCC1>[C:19]([C:18]([NH:17][C:12]([C:9]1[N:10]=[CH:11][C:6]([CH:2]2[O:3][CH2:4][CH2:5][O:1]2)=[CH:7][C:8]=1[C:15]([OH:14])=[O:16])=[O:13])([CH3:25])[CH:22]([CH3:24])[CH3:23])(=[O:20])[NH2:21]

Participants

4

Reactant 2

HCID 97937732-Amino-2,3-dimethylbutanamideHCID 15672408HCID 15672408, compound

Product 1

HCID 15672409HCID 15672409, compoundYield 128.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 5-(1,3-dioxolan-2-yl)-2,3-pyridinedicarboxylic anhydride (2.64 g, 0.012 mol) and 2-amino-2,3-dimethylbutyramide (1.55 g, 0.012 mol) in tetrahydrofuran is stirred for 2 days at room temperature. The reaction mixture is concentrated in vacuo to give the title compound as an orange oil (5.4 g, 100%), identified by NMR spectra analysis.

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-8feeeabee414483080f43813800d7387
Source dataset
uspto-grants-1995_04
Patent number
US05405827

Reaction notes

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