反应详情

To a solution of 3-[1-(2-phenylethyl)-2-pyrrolidinyl]phenol (0.83 g) in dry tetrahydrofuran (40 ml) was added methyl isocyanate (0.20 ml) followed by milled potassium carbonate (0.51 g)) at ambient temperature, under nitrogen. The reaction mixture was stirred for 4 hrs, filtered through a pad of celite, and the solids were washed with ethyl acetate. The combined filtrates were concentrated, and the residue was purified by flash column chromatography (silica gel 30-75% ether/heptane). The appropriate fractions were collected and concentrated to afford 0.84 g (84%) of product. The analytical sample was prepared by flushing the compound through alumina with ether.

1. filtrationfiltered through a pad of celite
2. washthe solids were washed with ethyl acetate
3. concentrationThe combined filtrates were concentrated
4. customthe residue was purified by flash column chromatography (silica gel 30-75% ether/heptane)
5. customThe appropriate fractions were collected
6. concentrationconcentrated