Sulfuric Acid → HCID 135508003, compound

HRID 1654081Notes

Reaction equation

HRID 1654081 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[CH3:8].[N+]([C:13]1[CH:14]=C(S([O-])(=O)=O)C=C[CH:18]=1)([O-])=O.[Na+].S(=O)(=O)(O)O>OCC(CO)O>[OH:9][C:4]1[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]2[C:3]=1[CH:18]=[CH:13][CH:14]=[N:1]2

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 178203-Amino-p-cresolHCID 31389Sodium 3-nitrobenzenesulfonate

Product 1

HCID 135508003HCID 135508003, compoundYield 5.8%

Reagents, catalysts & solvents 1

HCID 753GlycerolSolvent

Procedure

Following the same procedure as in Example 23-(a), reaction and treatment were carried out using 3.9 g of 3-amino-4-methylphenol, 7 ml of glycerol, 8.7 g of sodium m-nitrobezene sulfonate and 29 ml of a 80% aqueous sulfuric acid solution in order to obtain 290 mg of 5-hydroxy-8-methylquinoline.

Workup

  1. customas in Example 23-(a), reaction and treatment

Sources & evidence

ORD record
ord-15983ea33e2747b399028b0adbd06381
Source dataset
uspto-grants-1995_04
Patent number
US05405843

Reaction notes

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