1,3-Dibromopropane → 5-(3-Bromopropoxy)quinoline

HRID 1654087Notes

Reaction equation

HRID 1654087 reaction equation
O[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[Br:12][CH2:13][CH2:14][CH2:15]Br.CC([O-:21])(C)C.[K+]>>[Br:12][CH2:13][CH2:14][CH2:15][O:21][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:9]=1[CH:10]=[CH:11][CH:2]=[N:3]2

Participants

4

Reactant 3

HCID 80011,3-DibromopropaneHCID 23665647Potassium tert-butoxideHCID 178515546HCID 178515546, compound

Product 1

HCID 200790485-(3-Bromopropoxy)quinoline

Procedure

Following the same procedure as in Example 1-(a), reaction and treatment were carried out using 1.0 g of -hyroxyquinoline, 2.1 g of 1,3-dibromopropane and 0.78 g of t-BuOK as a base, in order to obtain 0.65 g of 5-(3-bromopropoxy)quinoline.

Sources & evidence

ORD record
ord-b65d260880a74dbeb3475e00608cd56c
Source dataset
uspto-grants-1995_04
Patent number
US05405843

Reaction notes

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