Potassium Carbonate → HCID 20079018, compound

HRID 1654091Notes

Reaction equation

HRID 1654091 reaction equation
[C:1]([N:4]([CH2:15][CH:16]([O:37]C(=O)C)[CH2:17][N:18]1[CH2:23][CH2:22][N:21]([CH:24]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:20][CH2:19]1)[C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][CH:9]=[N:10]2)(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO.O>[C:1]([N:4]([CH2:15][CH:16]([OH:37])[CH2:17][N:18]1[CH2:19][CH2:20][N:21]([CH:24]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH2:22][CH2:23]1)[C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][CH:9]=[N:10]2)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 20079041HCID 20079041, compound

Product 1

HCID 20079018HCID 20079018, compoundYield 98.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

In a mixed solvent of 10 ml of methanol and 5 ml of water were dissolved 0.55 g of 5-[N-acetyl-(2-acetoxy-3-(4-diphenylmethylpiperazine-1-yl)propylamino)]quinoline and 0.5 g of potassium carbonate, and the liquid was allowed to stand at room temperature overnight. The liquid was extracted with methylene chloride, and the extract was then dried with anhydrous magnesium sulfate and was concentrated to obtain 0.5 g of the desired compound.

Workup

  1. extractionThe liquid was extracted with methylene chloride
  2. dry with materialthe extract was then dried with anhydrous magnesium sulfate
  3. concentrationwas concentrated

Sources & evidence

ORD record
ord-20d067edbb4b4edea146fef2a3ab30ae
Source dataset
uspto-grants-1995_04
Patent number
US05405843

Reaction notes

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