反应详情

In ethyl acetate (20 ml) was dissolved (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol (compound 43, 0.48 g) followed by addition of 25% hydrogen bromide-acetic acid (0.7 ml). The reaction mixture was diluted with 100 ml of hexane and the resulting powder was collected by filtration and dissolved in ethyl acetate (10 ml). The solution was allowed to stand after addition of ethyl ether (20 ml) and the resulting crystals were collected by filtration to yield compound 43 hydrobromide (0.35 g) as colorless platelets. m.p. 180°-185° C.

1. filtrationthe resulting powder was collected by filtration
2. dissolutiondissolved in ethyl acetate (10 ml)
3. additionafter addition of ethyl ether (20 ml)
4. filtrationthe resulting crystals were collected by filtration