Hydrochloric Acid → HCID 22314793, compound

HRID 1654439Notes

Reaction equation

HRID 1654439 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[C:15]1(=O)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1.[C-:22]#[N:23].[K+]>O>[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([C:15]2([C:22]#[N:23])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 7967CyclohexanoneHCID 9032Potassium CyanideHCID 759941-Benzylpiperazine

Product 1

HCID 22314793HCID 22314793, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
0 °C

Procedure

1-benzylpiperazine (Aldrich Chemical Co., Inc., supra) (6.12 g) was dissolved in 10 mL deionized water and cooled to 0° C. Concentrated hydrochloric acid (3.6 mL) was added to adjust the pH to 5.After warming to room temperature, 3.6 mL cyclohexanone was added, followed by potassium cyanide (2.4 g) in 6 mL deionized water. The solution slowly became cloudy. After 18 hours, the solid was filtered. The solid was dissolved in chloroform, dried over Na2SO4, filtered and the solvent was removed in vacuo to yield pure 1-benzyl-4-(1-cyanocyclohexyl) piperazine.

Workup

  1. temperaturewarming to room temperature
  2. filtrationthe solid was filtered
  3. dissolutionThe solid was dissolved in chloroform
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-9871ee3b14cd4ed492d69ee9d01d6813
Source dataset
uspto-grants-1995_04
Patent number
US05407834

Reaction notes

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