Hydrochloric Acid → HCID 15295919, compound

HRID 1654547Notes

Reaction equation

HRID 1654547 reaction equation
C([O:3][C:4](=[O:25])[C@@H:5]([OH:24])[CH2:6][NH:7][C:8]([C:10]1([CH2:19][S:20]C(=O)C)[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11]1)=[O:9])C.[OH-].[Na+].Cl>>[SH:20][CH2:19][C:10]1([C:8]([NH:7][CH2:6][C@@H:5]([C:4]([OH:25])=[O:3])[OH:24])=[O:9])[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15295918HCID 15295918, compound

Product 1

HCID 15295919HCID 15295919, compound

Procedure

To the product of Example 6 (0.19 g, 0.52 mmol) in ETOH, add 1.0N NaOH (3.0 ml), stir 45 min and add 1.0N HCl (3.0 ml). Extract with EtOAc, dry and concentrate to obtain the title compound as a gum, [α]D26 =+2.8° (EtOH)

Workup

  1. extractionExtract with EtOAc
  2. customdry
  3. concentrationconcentrate

Sources & evidence

ORD record
ord-76f4f63912fd4a6e88dec23a1726788c
Source dataset
uspto-grants-1995_04
Patent number
US05407960

Reaction notes

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