Dimethylformamide → HCID 178517943, compound

HRID 1654704Notes

Reaction equation

HRID 1654704 reaction equation
[NH2:1][C:2]1[N:3]([C:20](=[O:22])[NH2:21])[N:4]=[CH:5][C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:9][CH:8]=1.[CH:23]([O-])([O-])OCC.CN(C)C=O>C(OCC)(=O)C>[CH2:13]([C:10]1[CH:9]=[CH:8][C:7]([C:6]2[CH:5]=[N:4][N:3]3[C:20]([OH:22])=[N:21][CH:23]=[N:1][C:2]=23)=[CH:12][CH:11]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 152804693-Amino-4-(4-benzylphenyl)-2-carbamoylpyrazoleHCID 53630039Ethylorthoformate

Product 1

HCID 178517943HCID 178517943, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 3-amino-4-(4-benzylphenyl)-2-carbamoylpyrazole (1.00 g), ethyl orthoformate (0.61 ml) and N, N-dimethylformamide (0.86 ml) was stirred at 100° C. to 110° C. for 45 minutes. To the reaction mixture was added ethyl acetate (20 ml). After stirring at room temperature for 30 minutes, the precipitate was separated by filtration, washed with ethyl acetate, and dried to give the title compound (0.72 g).

Workup

  1. stirringAfter stirring at room temperature for 30 minutes
  2. customthe precipitate was separated by filtration
  3. washwashed with ethyl acetate
  4. customdried

Sources & evidence

ORD record
ord-7ed1ab4887c04d8dbcc7cfb2f254b503
Source dataset
uspto-grants-1995_04
Patent number
US05409928

Reaction notes

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