Dimethylformamide → HCID 178424832, compound

HRID 1654716Notes

Reaction equation

HRID 1654716 reaction equation
[NH2:1][C:2]1[N:3]([C:21](=[O:23])[NH2:22])[N:4]=[CH:5][C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=2)=[CH:9][CH:8]=1.[CH:24]([O-])([O-])OCC.CN(C)C=O>C(OCC)(=O)C>[OH:23][C:21]1[N:3]2[N:4]=[CH:5][C:6]([C:7]3[CH:12]=[CH:11][C:10]([CH2:13][C:14]4[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=4)=[CH:9][CH:8]=3)=[C:2]2[N:1]=[CH:24][N:22]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 20076639HCID 20076639, compoundHCID 53630039Ethylorthoformate

Product 1

HCID 178424832HCID 178424832, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 3-amino-2-carbamoyl-4-{4-(3-methylphenylmethyl) phenyl}pyrazole (3.0 g), ethyl orthoformate (2 ml) and N,N-dimethylformamide (4 ml) was heated and stirred at 100° C. to 110° C. After 1 hour, to the mixture was added ethyl acetate (50 ml). The precipitate was separated by filtration, washed with ethyl acetate, dried to give the title compound (2.0 g).

Workup

  1. temperaturewas heated
  2. customThe precipitate was separated by filtration
  3. washwashed with ethyl acetate
  4. customdried

Sources & evidence

ORD record
ord-e651eb73a21c467daec05ded60e75ee0
Source dataset
uspto-grants-1995_04
Patent number
US05409928

Reaction notes

Loading…