Acetone → HCID 20076787, compound

HRID 1654747Notes

Reaction equation

HRID 1654747 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:27])=[C:11]([N:14]4[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]4)[CH:12]=3)[C:7](=[O:28])[C:6]([C:29](=[O:34])[CH2:30][N+:31]([O-:33])=[O:32])=[CH:5]2)[CH2:3][CH2:2]1.CC(C)=O.[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42]>>[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42].[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:27])=[C:11]([N:14]4[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]4)[CH:12]=3)[C:7](=[O:28])[C:6]([C:29](=[O:34])[CH2:30][N+:31]([O-:33])=[O:32])=[CH:5]2)[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 180AcetoneHCID 6422Trifluoroacetic acidHCID 15287725HCID 15287725, compound

Product 1

HCID 20076787HCID 20076787, compoundYield 87%

Procedure

4.7 g of 1-cyclopropyl-6-fluoro-7-(4-t-butoxycarbonylpiperazin-1-yl)-3-(2-nitroacetyl)-1,4-dihydro-4-oxoquinoline obtained from Example 3 was dissolved in 20 ml of trifluoroacetic acid and then stirred for 10 minutes. The solvent was removed, and the solid formed after addition of 50 ml of acetone was filtered and then dried to obtain 4.25 g of the object compound

Workup

  1. customThe solvent was removed
  2. customthe solid formed
  3. filtrationwas filtered
  4. customdried

Sources & evidence

ORD record
ord-168dc9b8e1554d0799aaae58fe0aa00b
Source dataset
uspto-grants-1995_04
Patent number
US05409933

Reaction notes

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