反应详情

A mixture of 2-amino-3-(2,6-dichlorobenzyloxy)pyridine (2 g, 0.007 1 mol), phenyl isothiocyanate (1.15 g, 0.0085 mol) and toluene (10 ml) was heated under reflux for 1.5 hours, then cooled and diluted with ether to induce crystallisation of the product, which was recrystallised from ethanol/ether. Yield 1.2 g (42%), m.p. 148°-149 ° C.

1. temperaturewas heated
2. temperatureunder reflux for 1.5 hours
3. temperaturecooled
4. customcrystallisation of the product, which
5. customwas recrystallised from ethanol/ether