反应详情

Solid N-chlorosuccinimide (16.69 g) was added in portions to a stirred solution of 4-(quinolin-2-ylmethoxy)benzyl alcohol (26.58 g) and triphenylphosphine (32.89 g) in dichloromethane (600 ml) at 0°-5° C. The mixture was stirred for a further 1.5 hours at 0°-5° C. and then purified rapidly by pouring the mixture onto flash silica and eluting with petroleum spirit 40°-60° C.-diethyl ether (2:1) under vacuum.

1. custompurified rapidly
2. additionby pouring the mixture onto flash silica
3. washeluting with petroleum spirit 40°-60° C.-diethyl ether (2:1) under vacuum