反应详情

This compound was prepared from indole and methyl bromoacetate by the method described in Example 10, part i. The reaction mixture was worked up by concentrating in vacuo, diluting with water and extracting with ethyl acetate (3x). The combined extracts were washed with water (3x) and brine, dried and evaporated to an oil. The residue was purified by chromatography on flash silica eluting with petroleum spirit 40°-60° C.--diethyl ether (5:1, 2:1) to give the product.

1. concentrationby concentrating in vacuo
2. additiondiluting with water
3. extractionextracting with ethyl acetate (3x)
4. washThe combined extracts were washed with water (3x) and brine
5. customdried
6. customevaporated to an oil
7. customThe residue was purified by chromatography on flash silica eluting with petroleum spirit 40°-60° C.
8. customdiethyl ether (5:1, 2:1) to give the product